SeaChange Therapeutics is pleased to announce our newest product LivLong – The Ultimate Anti-aging Product combining Astragoloside IV, Cycloastragenol and Astralagus in a single capsule.
Comment: Barb and Jeannine have been testing the product for several weeks and have noticed some improvements already. Jeannine has ulcerative colitis as well as COPD and her colitis has gone into remission and heart rate has dropped as well. Easier breathing has also been noticed. Barbara has been able to turn down her oxygen one liter even when she went birdwatching at 8100 feet. We were so pleased with the results that we decided to sell the product ourselves.
LivLong stimulates Telomerase activity to stabilize DNA for a longer healthier life.
About LivLong
LivLong is being touted as a supplement that may treat or prevent diseases** such as:
- Cardiovascular diseases including central and peripheral vascular disease
- Crohn's disease and other immunological conditions
- Liver diseases including fibrosis and cirrhosis
- Lung diseases including pulmonary fibrosis, asthma, emphysema, and COPD
- Hematopoietic disorders (including anemia, thrombocytopenia, neutropenia and other cytopenias
Chronic inflammatory gastrointestinal diseases such as Barretts esophagus Disorders related to loss of proliferative capacity in stem cell or progenitor cell populations. Such conditions may include bone marrow failure syndrome, aplastic anemia, myelodysplastic anemia or myelodysplastic syndrome
Neurodegenerative diseases such as Parkinson's
Viral and opportunistic infections including HIV
- Various degenerative diseases, such as disease of the bones or joints, and connective tissues, macular degeneration, diabetic retinopathy
- Wounds or other acute or chronic conditions of the skin and its appendages, such as, for example, a burn, an abrasion, an incision, a graft, a lesion caused by an infectious agent, a chronic venous ulcer, a diabetic ulcer, a compression or decubitus ulcer, a mucosal ulcer, keloid formation, hair or pigment loss, and other structural aberrations of the skin and its appendages
- Cancer and precancerous conditions in which low telomerase or shortened telomeres are associated with genomic instability, or increased mutation rates, or loss of tumor suppressor functions, and consequently subjects have an increased risk of tumor initiation, tumor progression, or tumor recurrence
**THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE. We recommend that you should consult with your own physicians if you have an autoimmune disease before taking this supplement.
Precautions: At recommended doses, astragalus has no serious side effects and can generally be used safely. It does interact with other herbs and medications (see Possible Interactions section). If you are pregnant or breast-feeding, you should talk to your doctor before taking any medication, including herbs.
Possible Interactions: If you are being treated with any of the following medications, you should not use astragalus without first talking to your health care provider: Drugs that suppress the immune system -- Astragalus may counteract the immune-suppressing effects of cyclophosphamide, a medication used to reduce the chances of rejection in transplant recipients, as well as corticosteroids.
Research
We have conducted exhaustive research on the contents of LivLong and have listed some of the research information below.
Telomere Lengths and COPD
Telomere dysfunction in COPD
LivLong as a telomerase activator
Telomerase Activators and what they Really Do
The ingredients included in LivLong are Astragalus, Cycloastragenol and Astragaloside IV. These are claimed to act as telomerase activators.
Astragoloside IVand Colitis
Astragoloside IV and Parkinson's
Positive effects of Astragalus Extract On the Immune System
Cycloastragenol And Telomerase Activity
Astralagus, Astragoloside IV and Chronic Inflammation
Chronic Inflammation firewall Astralagus and Cancer
Lung Function
Astragoloside IV and Diabetes
Astragoloside IV and Heart Failure
Cycloastragenol
Cycloastragenol is a saponin derived from Astralagus root, which is used in traditional Chinese and Eastern medicine. Saponins are amphipathic (both hydrophilic and lipophilic) glycosides (sugar bound to a non-carbohydrate functional group) that are classified according to a soaplike foaming reaction that they exhibit when shaken in an aqueous solution. The pharmacology and pharmacokinetics of cycloastragenol have recently (as of 2010) become a newsworthy item due to their ability to up-regulate telomerase in cells, the first known agent to do so. Cycloastragenol also has lymphocyte-modulating properties due to the telomerase altering property. Cell senescence in most human cells (other than progressed cancerous cells and some reproductive cells) occurs after 75-100 divisions, a phenomenon known as the Hayflick limit. When a human is first conceived, the length of the telomeres averages about 15,000 bases (up to 2,500 TTAGGG repeat units) as measured by a process called terminal restriction fragment length analysis. The length then begins to decrease at a rate of about 100 bases per cell division. By the time a person is born, the average telomere length has already dwindled to about 10,000 bases and then throughout the rest of a person’s lifetime the average length of the telomeres gradually decreases to about 5,000 bases at which time the person’s cells lose the ability to divide. These cells are then senescent, and the person suffers and dies of old age. All normal human somatic cells have a finite number of times that they can divide and when this limit is reached cells are described as cellular senescent. Telomere shortening has been attributed as a main mechanism for cellular aging and for the lack of cellular functions associated with aging. Unlike what is seen in most somatic cells, in activated T cells telomerase activity is upregulated, resulting in increased telomere length. However, this brief period of telomerase induction only delays cellular senescence. Naturally, there is a great deal of interest in finding inducers of telomerase that may help delay the onset of cellular aging.There are various nutraceuticals that claim to both increase the health of individuals and delay the onset of cellular aging. The nutraceuticals resveratrol and cycloastragenol known for their ability to enhance T cell functions in vitro were studied. In this study the effect of these compounds on cellular proliferative capacity, levels of telomerase activity, surface markers and cytokine secretion of human CD4 and CD8 T cells were tested. The results showed that cycloastragenol moderately increase telomerase activity and proliferative capacity of both CD4 and CD8 T cells. These preliminary results suggest that nutraceuticals inhibit the onset of CD4 and CD8 cellular senescence.
